Startups Using AI Agents for a New Healthcare Vision

Bill Gates in 2023 had written, “ The real shift will come when agents can help patients do basic triage, get advice about how to deal with health problems, and decide whether they need to seek treatment. These agents will also help healthcare workers make decisions and be more productive.”

Cut to today in 2025, what he predicted is true indeed. AI agents are disrupting healthcare by going beyond basic automation to act as intelligent, self-sufficient systems. Unlike traditional technologies, these agents analyse data, learn from experience, and make real-time decisions to improve patient care, expedite hospital operations, and manage the revenue cycle better. From AI-powered diagnostics to personalised treatment suggestions, these innovations are reshaping the industry. As startups push the boundaries of AI-powered healthcare, a new vision emerges which is intelligent agents driving precision medicine, optimising workflows, and transforming patient outcomes.

Tempus

Founder: Eric Lefkofsky
Tempus AI has enhanced its generative AI assistant, Tempus One, with new capabilities powered by its proprietary Agent Builder, designed to transform clinical decision-making and research. Key additions include:

• Patient Query Agent – Scans structured and unstructured medical records, such as physician notes and pathology reports, to match patients with clinical trials more efficiently.
• Patient Timeline – Uses AI to consolidate complex medical histories into a structured, easy-to-navigate timeline, giving physicians a clearer view of a patient’s treatment journey.
• Prior Authorization Agent – Automates the tedious process of compiling policy guidelines, drug labels, and patient data to streamline insurance approvals.

Innovaccer

Founders: Abhinav Shashank, Kanav Hasija, and Sandeep Gupta
Innovaccer has launched Agents of Care, a suite of voice-activated AI agents designed to reduce administrative burdens and enhance patient interactions. These AI-driven agents leverage unified clinical and claims data to provide a 360-degree view of patient information, enabling seamless coordination across care teams. Key capabilities include:

• Appointment Scheduling & Management – Automates booking, follow-ups, and reminders while providing patients with necessary visit details.
• Referral Agent – Calls patients to schedule specialist appointments, ensuring they have the required documents and information.
• Discharge Planning & Follow-ups – Engages with patients post-hospitalization, checks on their recovery, and schedules necessary follow-up care.
• 24/7 Patient Inquiry Support – Provides real-time answers to routine medical questions, improving accessibility and reducing staff workload.
• Prior Authorization & Care Gap Closure – Streamlines approvals and helps clinicians address gaps in care by leveraging real-time patient data.

Kairo Health

Founders: Jake Goldman and Ajay Vasisht
Kairo Health is redefining healthcare operations with AI agents that act as a scalable workforce, automating routine tasks to alleviate staffing shortages. These AI-driven solutions seamlessly integrate into existing workflows by capturing staff actions and converting them into executable instructions. Key capabilities include:

• Automated Patient Communication – Manages appointment reminders, follow-ups, and routine patient interactions, reducing administrative workload.
• Late Cancellation Management – Quickly identifies and contacts available patients to fill last-minute appointment slots, minimizing disruptions.
• Clinician Callout Handling – Notifies affected patients, finds the earliest available provider, and reschedules appointments efficiently.
• Workflow Automation – Learns and adapts over time to optimize care coordination, scheduling, and operational efficiency.

Penciled

Founder: Shawn Shivdat
Penciled’s AI agent, Nicole, is a powerful automation tool designed to help physical therapists maximize appointment bookings and reduce revenue loss from cancellations.

• Automated Scheduling: Nicole proactively fills last-minute cancellations by reaching out to patients on waitlists via text and phone calls.
• Multilingual Communication: Patients can interact with Nicole in multiple languages, improving accessibility and engagement.
• EHR Integration: Nicole seamlessly books confirmed appointments directly into the clinic’s Electronic Health Record system.
• Parallel Patient Contact: Unlike manual scheduling, Nicole can contact multiple patients simultaneously to secure an open slot faster.
• Efficiency & Revenue Impact: With an average booking time of just 3 minutes, Nicole fills 79% of cancellations, helping clinics generate up to $1.8k per week in recovered revenue.

Helpcare AI

Founders: Huzaifa Sial and Ayush Tomar
Helpcare AI’s autonomous agents handle the heavy lifting of care coordination, ensuring healthcare staff can focus on patient care while reducing administrative bottlenecks. These AI agents identify care gaps, reach out to patients in 29 languages via phone, text, email, and mail, and schedule essential screenings and visits. With no integrations required, they seamlessly navigate different systems and workflows, functioning just like human staff. Their efficiency is reflected in an 80% conversation-to-booking rate, ensuring that more patients receive the care they need without overwhelming healthcare teams.

• EMR & Data Processing: AI analyzes 1,108 EMR systems, pulls data from 2,637 payors, and generates reports to streamline workflows.
• Scalable Outreach: Capable of making up to 100 calls per minute, significantly reducing care coordination delays.
• Automated Care Coordination: AI autonomously schedules pre-operative procedures, medication reviews, and patient onboarding.
• Revenue & Impact: Clinics using Helpcare AI have closed 67% of identified care gaps, leading to improved patient outcomes and operational efficiency.

Rada

Founders: Gautam Sharda and Patrick Foster
Rada’s AI voice agents take over time-consuming insurance calls for healthcare providers, freeing up staff to focus on patient care. These agents navigate IVR menus and conversationally interact with insurers to verify patient eligibility, obtain prior authorizations, and check billing statuses. By integrating with Practice Management Software, Rada ensures seamless access to patient details, allowing staff to submit call requests effortlessly through a HIPAA-compliant portal. This automation not only reduces administrative costs but also accelerates reimbursements and minimizes billing surprises for both practices and patients.

• Automated Insurance Calls: AI agents handle eligibility verification, pre-auth requests, and claim follow-ups.
• Conversational AI: Agents speak naturally with insurers, navigating complex IVR menus efficiently.
• Seamless Integration: Directly connects with Practice Management Software for accurate call context.
• Cost & Time Savings: Reduces administrative burden, helping practices scale without increasing overhead.

Beam AI

Founders: Jonas Diezun and Aqib Ansari
Beam AI’s autonomous agents streamline healthcare operations by automating critical workflows, from patient intake to appointment scheduling and care planning. These AI-driven agents are trained on existing documentation and past cases, enabling them to understand, ask questions, and adapt—just like a human assistant. With Agentic Process Automation (APA), healthcare providers can deploy customizable AI agents to handle appointment support, patient care coordination, compliance automation, and data processing. Beam AI’s platform integrates seamlessly with existing EHR and practice management systems, allowing for a scalable, no-code approach to optimizing patient interactions and administrative efficiency.

• AI-Powered Patient Support: Agents assist with scheduling, eligibility verification, and follow-ups.
• Customizable AI Agents: Tailor workflows for specific healthcare needs, from intake to billing.
• Integration with Healthcare Systems: Works with EHRs and practice management platforms.
• Automation for Administrative Tasks: Reduces manual workload for staff, improving efficiency.
• Improved Patient Experience: Provides quick, accurate responses and streamlines care coordination.

Owkin

Founders: Thomas Clozel
Owkin’s AI agents act as research copilots, continuously analyzing vast multimodal datasets—including genomics, histopathology, and clinical records—to uncover new disease biology. These AI-driven systems integrate with Owkin’s federated data network and cutting-edge lab, enabling a seamless cycle of discovery, validation, and refinement. By leveraging Large Multimodal Models (LMMs), the agents extract actionable insights that fuel drug development, biomarker discovery, and precision diagnostics.

• AI-Powered Discovery – Identifies biomarkers, drug targets, and patient subgroups by learning from real-world and experimental data.
• Automated Research Assistance – Supports hypothesis generation, literature review, and molecular design, reducing manual workload for scientists.
• Agentic Robotic Lab Integration – Future iterations will enable AI agents to autonomously run experiments, optimize protocols, and refine research strategies, bringing Owkin closer to AI-driven scientific breakthroughs.