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Generate:Biomedicines Spearheads the Future of Generative AI in Medicine at J.P. Morgan Healthcare Conference

Generate:Biomedicines revolutionizes drug development with its groundbreaking clinical pipeline and expanded Amgen collaboration, leveraging generative AI to transform the future of medicine.

Generate:Biomedicines, a pioneering force in the application of generative artificial intelligence (AI) in drug development, announced significant advancements in its clinical pipeline and expanded collaboration with Amgen at the 42nd Annual J.P. Morgan Healthcare Conference.

Clinical Breakthroughs and Strategic Collaborations

Mike Nally, CEO of Generate:Biomedicines and CEO-Partner at Flagship Pioneering, will present the company’s strides in generative biology, emphasizing the dosing of the first patient in the GB-0895 study, advancements in the GB-0669 phase 1 study, and an expansion of their collaboration agreement with Amgen.

“In 2023, we made substantial advances in computational and experimental capabilities, shaping the future of generative biology,” said Nally.

Key Highlights from Generate:Biomedicines’ Pipeline:

  • GB-0895: An anti-TSLP monoclonal antibody for mild-to-moderate asthma, with the first patient dosed in the UK. The study, also conducted in Germany, focuses on safety and tolerability, aiming to select optimal doses/regimens for further development.
  • GB-0669: Targeting a critical region of the SARS-CoV-2 spike protein, this monoclonal antibody has shown safety in initial cohorts and potent in vitro neutralization of major variants.

Industry-Leading Generative AI Platform

The Generate Platform demonstrates exceptional multiparameter co-optimization capabilities, producing assets with best-in-class profiles. This includes potent anti-IL-13 monoclonal antibodies for type-2 inflammation-mediated diseases and anti-hemagglutinin antibodies targeting influenza. The platform’s success in generating de novo binders and deploying structure in the learning loop marks a significant innovation in therapeutic discovery.

Expanding Horizons with Amgen

The expanded collaboration with Amgen (NASDAQ: AMGN) represents a strategic step in combining Amgen’s therapeutic development expertise with Generate:Biomedicines’ leadership in generative biology. Alex Snyder, MD, EVP of R&D at Generate:Biomedicines, expressed enthusiasm for the collaboration, emphasizing the mutual goal of delivering best-in-class therapies for significant unmet patient needs.

The Promise of Generative Biology

Generative biology, driven by AI, is transforming therapeutic development. This paradigm shift promises to move beyond trial-and-error methods, enabling programmable drug generation that is faster, more cost-effective, and better tailored to specific conditions.

About Generate:Biomedicines

Founded by Flagship Pioneering and launched in 2020, Generate:Biomedicines is at the forefront of creating new drugs on demand across various biologic modalities. Its machine learning-powered generative biology platform, the Generate Platform, significantly accelerates the identification and validation of targets and therapeutics.

For more information, visit Generate:Biomedicines’ website.

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